John's Fun Projects - Immortality

Immortality

In case you aren't aware, this is a thing now. It's been in the regular news for at least 5 years.

This isn't complete immortality/invincibility obviously, just reversal of aging, you can still get hit by a car or die in any other way besides aging, especially cancer.

I'm basically just going to take some supplements to try to increase my body's levels of a coenzyme called nad+, but i have a really original idea about how to do it in a way that will allow me to avoid its pitfalls. I don't think this idea has been tried or thought of before. I didn't get here exactly in the way you would think, i kind of knew of this part of the internet but i had avoided it for many years and only really looked into this this stuff just recently because I had a surgery where I had a lot of lipomas removed, and i tried to look into what type of cells they were and what might be causing them.

warning, this page is a work in progress, I haven't taken any vitamins or done anything at all yet, this is a new subject to me. I have no medical knowledge, I don't know anyone who has any medical knowledge, and i'm sure anyone who did wouldn't be into this. I'm not just going to make disclaimers all the time though, i have to do this as if i think it's real, so this is the last one.

Below I plan to include definitions, video links, my plan, etc.


1 minute summary of my plan

I'm going to take two supplements, quercetin and nmn, but i'm going to wait a long time before i start taking the nmn.

1. do not take nmn right away

2. For a period of time take Quercetin, and possibly change diet and find other supplements in order to clear out senescent cells(they can cause cancer if they are present when you increase nad+).

3. during this period of time i will also lose weight, generally get more healthy, and research other "preperations" I can do before i actually start increasing nad+.

4. eventually focus on increasing nad+, when i think my body is prepared to do it.

5. Gain two incredible powers, immortality and immortal healing.

6. Declare myself immortal, start acting like an immortal, dressing like an immortal, doing immortal things.


2023 Vitamin List and plan for vitamin shelf

list of basic, non-scary, immortality inducing vitamins

Vitamin Name Why?
b12 stops grey hair
d3 helps immune system
k2 calcium assignment
magnesium helps sleep
omega 3 good for eyes
multi vitamin general health

I am going to pretty much give these to everyone i can, as of 10/3/2023, i think they're perfectly safe, risk free, boring vitamins, i don't want to make it overwhelming and have it be like you're taking 20 pills a day, so i'm just going to have 1 be taken every day. I will eventually also put together an advanced list that will possibly be added to this, that i might add after the 2 month antisensecent protocol. in 2024. I will also try to think of an antisensecent protocol list. I kept it to 7 to have only 1 for each day.


vitamin shelf idea

I'm going to make a small shelf or stand or box that sort of follows the above table, and has each vitamin with detailed cards explaining why.


The most important resources i've found and/or videos i've watched

one of the first videos i found and still one of the most important things i've found about this subject is this one by life and diy. She seems exactly like me in terms of the symptoms she has, from the migraines and sinus issues right down to the shoulder problems. I've never heard someone describe how i feel symptom-wise better than the girl in this video, she's crazy. I am going to try to do the same tests or types of tests that she did, and i'll probably take the liposomal nad booster in time, after i do the other things and get an initial test. I have already started eating turmeric, in my case in the form of a tumeric, carrot, ginger, and lemon drink, to be mentioned in health journal and maybe in excercise too. So the things i've taken from this video that i plan to act on are 1. exercise 2. quercetin and liposomal nad supplements 3. eat tumeric 4. get tested.

This video made me think that i really need to kill(by taking quercetin?) senescent cells before i take nad+, this guy also has pretty good videos and ideas overall. I like his graphic, see below. now this is unfortunately further complicated by what judith campisi has to say, and the fact that not all senescent cells are bad, and there's at least 140 different kinds of senescent cells, which yes i actually plan to list and define. So this guy's understanding of senescent cells as just the bad guys unfortunately isn't entirely right, it's not that simple. I like his start stop idea though, the clearing them out idea, the being aware of the threat of cancer being accidentally caused by boosting nad+ without killing senescent cells idea. (killing them first before ever taking/boosting nad+ instead of killing them while boosting nad+ at the same time is my own idea.) I would clear them out then boost nad+, then kind of stop or pull back for a while, so that maybe the good senescent cells, the ones that promote healing for example can come back. Or maybe i could find a type of senescent cell that is actually always bad and just kill it, but even then i found that to be complicated as senescent cells themselves have life cycles and are good at some points of their life cycles and bad at other points, or good for you to have at certain ages and bad to have at other ages. So this is complicated, immortality is hard, but this video has been one of the ones that gets me thinking the most. All the possible problems with this are why so far i've just started eating tumeric and excercising more, and haven't yet committed to or taken any supplements, though i do have a bottle of quercetin that i've never taken.

tenacity

Definitions, terms, and people.

nad: A "coenzyme central to metabolism". Nad stands for nicotinamide adenine dinucleotide. It has two "halves", nad+ and nadh. nad+ has been oxidized(-1 electron), nadh has not.

nad+: The oxidized half of nad. This is the main thing that apparently needs to be increased in order to increase lifespan. Of course it does lots of good things like turn food into energy.

nadh: nadh is nad with hydrogen, it's the other half of nad. It seems to do many of the same things nad+ does, but people seem to not care about increasing it, or maybe think they can't increase it as much as nad+.

nmn: Directly increasing NAD+ is not very effective, you can't just eat nad+ and have more of it, you have to activate it with other things. NMN is a nad+ activator, aka an nad+ precursor.

senescent cell: A cell that has stopped dividing, lives longer, acts different, and generally spreads messages through different chemical signals. People produce more sensecent cells as they get older. Senescent cells come in many varieties and can be both good and bad. They contribute to many good things like wound healing. there are different types of senesent cells, some types are good, some types are bad, sometimes the same ones do good things and then start doing bad things. Maybe I can find out all of the types and find one that's always bad, or clear them out for a little while, take the nmn, then after a little while stop taking the nmn and get them back. Maybe doing a plan like this for 2 months out of every year would help. I don't know. I haven't taken anything yet. They can both prevent and cause cancer depending on the situation. It's complicated. Killing the right types of senescent cells at the right time and figuring out how to get this exactly right and not make a mistake is a key part of attaining immmortality and immortal healing. My plan right now is 1. reduce the number of the bad types of senescent cells significantly, 2. increase nad+ levels at a safe time.

nr: Seems to be another nad+ activator/precursor.

lipoma: A benign fatty tumor underneath your skin. I have been getting tons of these. They are considered harmless. They might also be senescent cells.

quercetin: An antioxident that probably kills senescent cells, might reduce inflammation, and might be good for migraines.

resveritrol: Kind of another nad+ precursor, but also effects sirtuins.

sirtuins: Signaling proteins that repair dna. I think when they repair it wrong, aging can happen.

Senolytics: actually means molecules that destroy senescent cells, but seems to be often used incorrectly in conversation to mean the "study of" molecules, drugs, or foods that eliminate or destroy senescent cells.

related people

There's lots of people who talk about this stuff. I don't think it will help anyone for me to write long paragraphs about how i feel about each one of these jokers so I'm going to just list of names of the people who talk about this stuff, maybe their profession in one word, along with a rating between 1(low, bad) and 5(high, good) of two things, their importance(importance to the subject/field. they're probably more important if they did a successful study on mice or wrote a book or something, though i like good ideas and interviews too, but the purely entertaining people won't get past 2 or 3) and how trustable they are (in a subject like life extension, there's a high number of frauds, or people who really believe what they're saying and even bet their lives on it but are just wrong/incorrect, because this is an attempt to do something that is pretty close to impossible). Also do i think they think that immortality(defining that as living over 150 years using these types of ideas) is currently possible.

David Sinclair, scientist(5, 1, Y)
Judith Campisi, scientist(3, 5, N)
life and diy, youtuber(2, 4, Y)
Lance Hitchings, youtuber(2, 3, Y)

below are some random definitions and thoughts i started writing, i had them commented out, but now decided to just include them.

david sinclair: an eccentric scientist who I currently don't like. Possibly a snake oil salesman, though its hard to say. He is the main person who found out nad+ reverses aging in mice, and has several podcasts and interviews about the topic of life extension all over the internet. I don't like him because he seems to be trying to patent what should be a supplement so he can sell it as a pharmaceutical drug and make millions of dollars. I think if he's a genius who studies at harvard and he's so smart and all, he could easily make millions of dollars selling candy at the dollar store instead, not trying to lock down ownership of a subset of knowledge that yes he is responsible for the creation of, but that is a life and death thing to so many people. Capitalism can be fun, at toys r us, but in my opinion it doesn't belong in the emergency room. A firefighter shouldn't ask for a tip before he climbs up to get a baby out of the window of a burning building. It's not like david sinclair is going to be impoverished if he can't patent this work. He could make millions anyway just by having his own supplement brand. I don't know why he wants to go the typical big pharma, drug discovery way with it, but i suppose harvard brainwashed him to do that. Harvard has produced a lot of problemmatic people in history. Luckily, nmn was sold as a supplement almost a hundred years before he discovered this particular use for it, so he can't patent it, and you can buy it on Amazon pretty easily... Somewhat unrelated, but he also claims he makes tiny human brains the size of peas and does horrifying experiments on them.

Judith Campisi: a nice old lady, Seems like an actual scientist. Doesn't seem crazy, greedy, or particularly creepy. Seems to know a lot about senescent cells. here's an ok interview. She seems fine.


faq (formerly deleted, incomplete, used to be commented out)


do you want to live forever? It won't be forever, even a million years is a very short time. This might get you to like 1000 at most. geological processes take billions of years.

there's too many people already... you and i, we disagree, there's not very many people at all. There's 8 billion people, ok compare that to 100,939,140,000 viruses on earth or to 125 billion known galaxies. True overcrowding doesn't exist, people clump together in crowded cities, we don't need to do that, there's plenty of space, it's just a social thing. In cities with bad city planning or city plans designed in the middle ages or before, like ancient cities in india for example, they might have issues like plumbing systems that were not designed for their current population density. This is not really overcrowding, it's just lack of planning combined with our natural tendency to want to live extremely close to each other.

long lifespans will cause more pollution... not true either. Again lack of planning, and more frequently in modern times, extreme amounts of planning by governments and the companies that bribe and control those governments is the only reason for pollution.

Sorry but it's got nothing to do with you turning the lights off or throwing things in a green colored bin instead of a black colored one(both go to the same place). All oil pollution and plastic production was created by international treaties over decades as part of the creation of the petro dollar. You could have glass bottles instead of plastic bottles, you could have electric trains that work with cars to make a better transportation system, you could have unlimited pumped storage hydroelectric power. We essentially almost did have all of those things at the beginning of the 1900's, (think of the old glass coke bottles and bottles the milkman had) electric cars too, but those in power chose to tear up the local power sources like dams(which they got environmentalists to hate for killing fish, though there are better ways to build dams and there is also pumped hydro), and promote international trade, not to help people, though they'd be quick to point out it often did, but to make higher profits. They(don't think i can't name them, that's just not related to the supplement topic) took the power(electric and all other types of power) away from local areas and created an international supply chain on purpose, it took lots of effort, it wasn't some accident. To trust the same groups of people who created the problem to fix it is insane. Maybe if people lived longer, everyone would see it more, and be able to express it better, and the attempts to revolt against it wouldn't be so quick, unfocused, dumb, counter-prodcutive, easy to take advantage of, and unsuccessful.

why not just accept life as it is? ok, have you ever broken your arm? did you go to the hospital? why didn't you just accept what nature had coming to you? just go get eaten by a lion then. Me, I pretty much hate nature, the food chain, the life cycle, butterflies getting old and having their wings fall off, big fish eating little fish, etc. I oppose nature, and yes it will eventually beat me, but don't pretend you are one with it, if it had its way, you wouldn't exist. Most planets that nature controls have no atmosphere, they're icy wastelands. If you want to be one with nature, go stand on an asteroid with no helmet on and take a deep breath. Life defies and alters nature in order to exist. Life is constrained by horrible, unacceptable limitations that need to be broken. Now you may be able to win this arguement just by acting calm, meditative, and reasonable and saying, See? he's crazy. but then all i have to do is wait and then i'll eventually win the arguement because you will will die of old age and i'm immortal. So if you're dead, i'm the only one left standing, then no matter how unhinged i may be, i'll be the winner of this arguement, all i have to do is wait and then dance on your grave.

I could have brought up christian scientists dying after refusing medical treatments too, and putting their faith in god, and then pointed out how that's a very similar attitude, but i didn't want to. I thought it would be more fun to go with the i don't even need to argue with you, i'm immortal so i just need to wait for you to die route.

you are making emotional arguements, logical fallacies etc. Sure, but you are too. Whether or not to do this is entirely going to be based on how you feel. we can look at the same arguement and feel two different ways about it, and that's based on all sorts of things. I'm not saying you have to decide to be immortal(as in not age), that's a decision you have to make for yourself. Logically, we will eventually die, the universe will eventually be gone, so there's no reason for anything really, and words are just random sounds that we all agree upon, they have no meaning, it's all about how you feel. If you want to let yourself die or jump off a bridge, or suffocate yourself with a bag, or drown yourself in the kitchen sink, go right ahead. Was that some sort of illegal emotional comparision or something? well i'm probably going to keep doing it, so the only way for you to escape is to drive your car into a tree at 150 mph.

Now as for how you fight aging, that's an entirely more factual subject than if you should. I'm probably wrong about that too, but we would have to agree that at least that's a more solid, less emotional thing to talk about. But you can get emotional about that too if you want and you can go ahead and slice open your wrists right open if even the factual stuff makes you upset.

This is supposed to be an faq, why are your answers turning so violent? You're right, i'm sorry, it must be the immortal blood coarsing through my veins. Really i guess just not trying to be immortal, planning to slowly decline, and accepting death makes me feel sad and not normal, and trying to live a long healthy life and planning to improve over time, and eventually solve my problems feels more normal. I don't like feeling like the future's going to be horrible and painful. I think that's what old age is, i think it's a disease. It's either my life is over i'm dying, or my life has just started i have limitless potential. Yes the first one is probably true, but which one makes the day better? I guess now i'm the one arguing from a need for something like faith or love of nature to get through the day, so that's odd. in short it comes down to a simple attempting to become immortal = positive/happy/good future, accepting death = negative/sad/bad future or no future.

why not just have kids? well there's a lot wrong with me, so i don't usually even feel like leaving the house, and no supermodels were banging on my door today, just demanding to get pregnant, maybe you should ask them why, that has nothing to do with me, they go where they want.

I can speculate that they can see i've got lots of problems, and they wouldn't want their kids to have the same problems, or maybe i smell sick, like they can smell the germs and infections i have, or maybe the people on the internet are right and they get sick to their stomach and vomit right after they see me, which means that at work(unrelated to the models, they're no models, i don't like people at work), like hundreds of women, old and young are throwing up in the women's bathroom every day, multiple times a day, every time i walk past, all the customers too. All the girls in all my classes at school back in the day did this every day too. If this is true, they're all very polite. They also must be very good at not throwing up or waiting to throw up until i leave the room. Anyway, who knows what's going on with them? They don't really tell you anything. They don't talk or communicate in any real way, so it's hard to say.

Also, the stupid kids would die right away too, that's not particularly responsible. Unless i have the whole immortality thing already figured out, i'd basically be also killing them.

Also, those supermodels only last a few years, then they start dying of old age, they might have boobs, i understand that, but they have no real solutions to any real problems, when it comes to aging, being cool doesn't help them at all, they're just as doomed as i am. So they might be some sort of special person until they're 24, but then 20 years after that, after they do their one trick of getting pregnant, something they really don't even have that much to do with, they're just some mean old hr lady. They're going to get crushed too, just as hard as me, unless they can figure out how to reverse aging, which they are too closed minded to look into because they never learned to think weird thoughts because everything was going fine for them when they were young and when their learning speed was fast enough. So standard thinking worked the best for them at that critical time. In order for them to find out about what senescent cells are going to kill them and when, they'd need to reverse their age to 4, then get some sort of disease or allergies, then with their learning speed reset to a child's learning speed, those allergies or whatever would make them feel bad enough to allow them to start thinking unconventional thoughts. I wonder what happened to judith campisi that made her so weird and prevented her from being a model.

Also I don't know if my genes are related to me at all, i think they're just using me to spread themselves, and doing a terrible job of it too.

and i don't always think natural selection does great things to a species anyway. Goats are a good example. The females select the goat who is the best at bashing his head into the other guy and not getting dizzy etc. This isn't a great thing to be making your whole species good at doing. Tell that to a female goat though and she will ignore you completely and only have children with the winner of this competition which is kind of an anti competition because the winner is likely to be pretty stupid, and it's going to kill their species in the long term or at least prevent them becoming a true top of the food chain species. Now being a male with lots of problems like i already admitted, i might be blaming the females for this flawed process a bit too much. Males of all species also select for stupid stuff. Also maybe all people are passively, unconsciously trying to kill me just like crows always try to kill a white crow or something, so i should be mad at the guys too. What's attractive isn't always a good idea for survival or for having a good life, attractiveness and survival only loosely correlate sometimes in some environments. Also survival can mean lots of things. Fruit flies are excellent at surviving, but individual fruit flies appear to me to have a not so fun, and extremely short life. Penguins, at least the ones in antartica, are completely insane, they have this one homing trait that has caused them to nest in one place, and that one place became unlivable, but they found a way to live there, amazing, and yeah everyone likes penguins, but again maybe it creates a bad life with a lot of pain and has created many millions of unusual and painful deaths. None of them actually directly selected for that one either, they just all have an unhelpful homing trait, well it should be unhelpful, but they made it work, so this is complicated, but i don't want to walk all that way and stand in the cold like that, not every year at least. What if i truly don't like what my own species is doing? is it possible to go against that and still live, maybe even live well, and greatly outlive all the mindless drones?

Individually I'm a consciousness that is used as a tool by this immortal monster, that's not cool. if i go down, it should go down too. The immortal monster in this case being the genetic system, but i think the economic system, these governments, these corporations, whoever else, are another set of immortal monsters that use me from birth to death, and have everything all planned out, and have predicted all of my possible actions before I even get a chance to think of doing anything.

So you don't think my mind is part of your body? Half my body that isn't the 80% water is just germs and parasites and stuff, literally other animals, so even if i were my dna, there isn't even very much of that. I think i'm some sort of electrical field or electrical charge contained in a circuit, this electrical circuit is in the neurons in my brain, but it could probably be transferred to another place. Now to figure out how to do that i'd have to keep my body alive for a lot longer, i might not even be able to figure it out in 1000 years, but maybe i would, so that would be a good first step.

What's your problem man? I guess in a way i'd like to not follow a life cycle. I've seen other animals do it, i've seen the squirrels, even the hot girl squirrels, dying in my driveway, and i see my fellow humans being no different. Blindly following a sequence of birth, competition, reproduction, death, not questioning it, not thinking about it. Just because britney spears did some dance in a waterfall 20 years ago doesn't mean i personally should have to want to be annihilated in this way. And she went completely insane too, so why can't i? I think it's perfectly fine to want to not turn to dust. And if that means turning into a computer when i grow up or turning into a moon, then that's what i think i should do.

whats so bad about old age? hormone imbalances, lack of ability to learn quickly, shrinking muscles, low testosterone, weaker bones, inability to enjoy the day, grey hair, grumpiness, loss of ability to play mario kart, risk of the development of a psychotic sense of love for the 40 hour work week and all jobs no matter what the job is or whether it's actually accomplishing anything, obesity, heart attacks, blindness, loss of teeth, arthritis, osteoperoisis, broken hip bones, decreased athletic performance, memory loss, possibly increased frequency of migraine headaches in my case, etc. (will add more later)

will this be like highlander? We could definitely fight with swords, and have a house boat or barge, but unfortunately we are still human. I basically don't know how we'd get the quickening to happen, but i'm willing to keep my eye open for solutions to this problem.

deleted part of david sinclair definition: I've known of him and seen him pop up for several years, but i've mostly ignored it up until recently, when just some background research about a minor surgery i had brought me to look at his stuff in a legitimate way, not through accidental browsing. I was also thinking about exercise nutrition and about what to do overall with the common problem of trying to maintain physical activity after the age of 40 and how to resist the effects of aging. Anyway, while reading about that sort of normal stuff, i came across this part of the internet that i definitely knew was there, but had purposefully ignored up until now. I don't like him because he seems to be trying to patent what should be a supplement so he can sell it as a pharmaceutical drug and make millions of dollars.

The things you have to do to stop aging may cause you to die more quickly of something else, like cancer. I think it's possible to reverse aging by increasing your levels of something called nad+. This is a youtube rabbit hole that centers around this one weird guy named dr david sinclair. However, I don't really like him because he is trying to patent nad+ and make a ton of money off of it. Luckily, it was sold as a supplement already so he can't patent it. Much like Elon Musk didn't discover or invent the electric car, David Sinclair didn't discover or invent nad+.

nad itself is A coenzyme comprised of two nucleotides (i.e. one with adenine base and the other a nicotinamide). nad+ is its oxidized form nadh is its reduced form The main function of NAD+ is to transport high-energy electrons to the electron transport chain in aerobic respiration. Although this is its main function, it is also essential as a coenzyme in assisting many other reactions in the body such as immune response, circadan rhythm regulation, nitrogen fixation, converting food to energy, and DNA repair.

So, you can take it, or more accurately precursors of it like nmn and nr.